Dantrolene prevents arrhythmogenic Ca2+ release in heart failure
نویسندگان
چکیده
منابع مشابه
Dantrolene prevents arrhythmogenic Ca2+ release in heart failure.
In heart failure (HF), arrhythmogenic Ca(2+) release and chronic Ca(2+) depletion of the sarcoplasmic reticulum (SR) arise due to altered function of the ryanodine receptor (RyR) SR Ca(2+)-release channel. Dantrolene, a therapeutic agent used to treat malignant hyperthermia associated with mutations of the skeletal muscle type 1 RyR (RyR1), has recently been suggested to have effects on the car...
متن کاملDantrolene prevents arrhythmogenic Ca release in heart failure
Maxwell JT, Domeier TL, Blatter LA. Dantrolene prevents arrhythmogenic Ca release in heart failure. Am J Physiol Heart Circ Physiol 302: H953–H963, 2012. First published December 16, 2011; doi:10.1152/ajpheart.00936.2011.—In heart failure (HF), arrhythmogenic Ca release and chronic Ca depletion of the sarcoplasmic reticulum (SR) arise due to altered function of the ryanodine receptor (RyR) SR C...
متن کاملß-Blocker Timolol Prevents Arrhythmogenic Ca2+ Release and Normalizes Ca2+ and Zn2+ Dyshomeostasis in Hyperglycemic Rat Heart
Defective cardiac mechanical activity in diabetes results from alterations in intracellular Ca(2+) handling, in part, due to increased oxidative stress. Beta-blockers demonstrate marked beneficial effects in heart dysfunction with scavenging free radicals and/or acting as an antioxidant. The aim of this study was to address how β-blocker timolol-treatment of diabetic rats exerts cardioprotectio...
متن کاملNeuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release.
AIMS Sudden death resulting from cardiac arrhythmias is the most common consequence of cardiac disease. Certain arrhythmias caused by abnormal impulse formation including catecholaminergic polymorphic ventricular tachycardia (CPVT) are associated with delayed afterdepolarizations resulting from diastolic Ca2+ release (DCR) from the sarcoplasmic reticulum (SR). Despite high response of CPVT to a...
متن کاملAstragalus Granule Prevents Ca2+ Current Remodeling in Heart Failure by the Downregulation of CaMKII
BACKGROUND Astragalus was broadly used for treating heart failure (HF) and arrhythmias in East Asia for thousands of years. Astragalus granule (AG), extracted from Astragalus, shows beneficial effect on the treatment of HF in clinical research. We hypothesized that administration of AG prevents the remodeling of L-type Ca2+ current (ICa-L) in HF mice by the downregulation of Ca2+/calmodulin-dep...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2012
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00936.2011